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TBC1D7 Antibody, Biotin conjugated

Datasheet
Code CSB-PA873720LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TBC1D7 Polyclonal antibody
Uniprot No.
Q9P0N9
Target Names
TBC1D7
Alternative Names
TBC1D7 antibody; TBC7 antibody; HSPC239 antibody; TBC1 domain family member 7 antibody; Cell migration-inducing protein 23 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TBC1 domain family member 7 protein (1-293AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TBC1D7 Antibodies

TBC1D7 Proteins

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Target Background

Function
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Involvement in disease
Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH)
Subcellular Location
Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
Tissue Specificity
Highly expressed in heart, and slightly in kidney, liver and placenta.
Database Links

HGNC: 21066

OMIM: 248000

KEGG: hsa:107080638

STRING: 9606.ENSP00000348813

UniGene: Hs.484678

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